Persistent DNA damage in the placenta affects pregnancy outcomes

Scientists have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome. People with this rare genetic disorder often harbor mutations in cohesins, ring-like proteins that help DNA organize and repair itself.

source https://www.sciencedaily.com/releases/2020/06/200616113925.htm