Older, critically ill patients with COVID-19 may have increased risk of bradycardia with lopinavir and ritonavir

The combined use of antiretroviral medications lopinavir and ritonavir, previously used to treat SARS-Cov-1 and MERS-Cov patients, appeared to cause bradycardia in 22% of elderly, critically ill COVID-19 patients, in a small study in France. Bradycardia was resolved in all patients after discontinuation or dose reduction of both medications.

source https://www.sciencedaily.com/releases/2020/07/200709121236.htm