Why do some neurons degenerate and die in Alzheimer's disease, but not others?

Researchers have uncovered molecular clues that help explain what makes some neurons more susceptible than others in Alzheimer's disease. The scientists present evidence that neurons with high levels of the protein apolipoprotein E (apoE) are more sensitive to degeneration, and that this susceptibility is linked to apoE's regulation of immune-response molecules within neurons.

source https://www.sciencedaily.com/releases/2021/05/210506163640.htm