Regulation of protein homeostasis by cardiac glycosides

The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been associated with various human diseases, the compounds modulating UPR can clarify the pathological significance of the UPR.

source https://www.sciencedaily.com/releases/2021/06/210607095742.htm