Scientists boost gene knockdown in human cells via chemically modified RNA CRISPR

In the latest of ongoing efforts to expand technologies for modifying genes and their expression, researchers have developed chemically modified guide RNAs for a CRISPR system that targets RNA instead of DNA. These chemically-modified guide RNAs significantly enhance the ability to target -- trace, edit, and/or knockdown -- RNA in human cells.

source https://www.sciencedaily.com/releases/2021/08/210802140153.htm