Bridge recombinases, optimized for human cells, enable massive programmable DNA rearrangements

For decades, gene-editing science has been limited to making small, precise edits to human DNA, akin to correcting typos in the genetic code. Arc Institute researchers are changing that paradigm with a universal gene editing system that allows for cutting and pasting of entire genomic paragraphs, rearranging whole chapters, and even restructuring entire passages of the genomic manuscript.

source https://phys.org/news/2025-09-bridge-recombinases-optimized-human-cells.html