Impaired T cell function precedes loss of natural HIV control

A small subset of people, known as controllers, are able to suppress HIV naturally, without the need for medication. A small percentage of controllers ultimately lose the ability to suppress the virus. Researchers have found that aborted control is likely due to HIV-specific T cells losing the ability to replicate and kill infected cells, which can happen years before.

source https://www.sciencedaily.com/releases/2021/09/210909162220.htm